mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27

نویسندگان

  • Zhuoying Feng
  • Luping Zhang
  • Junchen Zhou
  • Shuai Zhou
  • Li li
  • Xuyan Guo
  • Guoying Feng
  • Ze Ma
  • Wenhua Huang
  • Fei Huang
چکیده

Glioma has become a significant global health problem with substantial morbidity and mortality, underscoring the importance of elucidating its underlying molecular mechanisms. Recent studies have identified mir-218 as an anti-oncogene; however, the specific functions of mir-218-1 and mir-218-2 remain unknown, especially the latter. The objective of this study was to further investigate the role of mir-218-2 in glioma. Our results indicated that mir-218-2 is highly overexpressed in glioma. Furthermore, we showed that mir-218-2 is positively correlated with the growth, invasion, migration, and drug susceptibility (to β-lapachone) of glioma cells. In vitro, the overexpression of mir-218-2 promoted glioma cell proliferation, invasion, and migration. In addition, the overexpression of mir-218-2 in vivo was found to increase glioma tumor growth. Accordingly, the inhibition of mir-218-2 resulted in the opposite effects. Cell division cycle 27 (CDC27), the downstream target of mir-218-2, is involved in the regulation of glioma cells. Our results indicate that the overexpression of CDC27 counteracted the function of mir-218-2 in glioma cells. These novel findings provide new insight in the application of mir-218-2 as a potential glioma treatment.

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عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2017